Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database

June 2023 in “ Dermatology and therapy ”

Prethibha George, Oladayo Jagun, Qing Liu, Charles Wentworth, Lynne Napatalung, Robert Wolk, Susan D. Anway, Samuel H. Zwillich

Alopecia Areata Alopecia Totalis Alopecia Universalis herpes simplex infection AA AT AU

Studysummary This study found that patients with alopecia areata had a higher incidence rate of herpes simplex infection compared to matched individuals without the condition.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study analyzed data from 8784 patients with Alopecia Areata (AA), including 599 with alopecia totalis or alopecia universalis (AT/AU), and compared them to 26,352 patients without AA. It found that AA patients had a higher incidence rate (IR) of herpes simplex infection than the non-AA cohort, with rates per 1000 person-years of 19.5 and 9.7 respectively. However, the rates of other outcomes, such as cardiovascular disease, malignancy, and thromboembolism, were similar between the two cohorts. Patients with AT/AU generally had higher rates of outcome events than those without AT/AU. The study suggests that it may be beneficial to screen for such conditions upon AA diagnosis for earlier treatment intervention.

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13 / 13 results

Prevalence of Autoimmune and Inflammatory Diseases and Mental Health Conditions Among an Alopecia Areata Cohort from a US Administrative Claims Database

research Prevalence of Autoimmune and Inflammatory Diseases and Mental Health Conditions Among an Alopecia Areata Cohort from a US Administrative Claims Database

1 citations , June 2023 in “Journal of Dermatology”

This study found that patients with alopecia areata had a higher prevalence of autoimmune, inflammatory, and mental health conditions compared to a matched cohort without alopecia areata.

Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States

research Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States

6 citations , July 2022 in “Journal of health economics and outcomes research”

This study found that US adolescents with alopecia areata, especially those with alopecia totalis or universalis, experience significantly higher healthcare costs and resource use compared to matched controls.

research Healthcare Utilization And Costs Among US Adolescents With Alopecia Areata

4 citations , July 2022 in “Journal of health economics and outcomes research”

This review discusses the economic burden of alopecia areata in adolescents and reports no new results; the authors note that evidence in this area is limited.

research Monotherapy for Alopecia Areata: A Systematic Review and Network Meta-Analysis

16 citations , January 2019 in “Skin appendage disorders”

This study used a network meta-analysis to compare alopecia areata treatments, finding that intralesional corticosteroids are most effective for mild cases, while diphenylcyclopropenone ranks highest for moderate to severe cases; further research on oral tofacitinib is needed.

research Treatment of Alopecia Areata: An Australian Expert Consensus Statement

95 citations , November 2018 in “Australasian journal of dermatology”

This consensus statement outlines a treatment algorithm for alopecia areata, discussing when to consider systemic treatment and how to assess outcomes, without providing new clinical results.

research Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis

100 citations , July 2018 in “Journal of The American Academy of Dermatology”

This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.

research Cancer Risk in Patients with Alopecia Areata: A Nationwide Population-Based Matched Cohort Study

15 citations , March 2018 in “Cancer Medicine”

This study found that alopecia areata patients had a slightly decreased overall cancer risk, with significantly lower risks for some cancers but higher risks for lymphoma, breast, kidney, and urinary bladder cancers.

research Review of Treatment for Alopecia Totalis and Alopecia Universalis

44 citations , April 2017 in “International Journal of Dermatology”

This study reviewed treatment options for alopecia areata totalis and universalis, finding no completely effective therapy. Promising treatments with quality data include diphenylcyclopropenone, squaric acid dibutylester, and photodynamic therapy, but larger, high-quality trials are needed.

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

355 citations , January 2017 in “Journal of the American Academy of Dermatology”

This review reports no new results and highlights existing research suggesting JAK inhibitors may be effective in treating inflammatory skin conditions like alopecia areata, atopic dermatitis, psoriasis, and vitiligo.

research Cardiovascular Risk in Patients with Alopecia Areata: A Propensity-Matched Retrospective Analysis

29 citations , May 2016 in “Journal of the American Academy of Dermatology”

This study observed that patients with alopecia areata had decreased odds of developing stroke and a potential decreased risk of acute myocardial infarction, though the latter was not statistically significant.

research Alopecia Areata Increases the Risk of Stroke: A 3-Year Follow-Up Study

25 citations , June 2015 in “Scientific Reports”

In this study, patients with alopecia areata were found to have a higher risk of stroke over a 3-year follow-up period compared to those without the condition.

research Overview of Alopecia Areata

110 citations , December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This article reviews current understanding of alopecia areata, its genetic and immune factors, and discusses ongoing research and treatment development, without presenting new experimental results.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.