Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis

February 2019 in “ Journal of The American Academy of Dermatology ”

Solam Lee, Hanil Lee, Chung Hyeok Lee, Won‐Soo Lee

TLDR People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

The systematic review and meta-analysis from 2019 found that patients with alopecia areata (AA) had a higher prevalence of several comorbid conditions compared to controls without AA. These conditions included atopic diseases, metabolic syndrome, Helicobacter pylori infection, lupus erythematosus, iron deficiency anemia, thyroid diseases, psychiatric diseases, vitamin D deficiency, and audiologic and ophthalmic abnormalities. Additionally, there was an increased risk of autoimmune diseases in AA patients. The study also reported that AA patients had lower odds of having certain other diseases, including diabetes mellitus and various cancers. The review called for larger studies to confirm these associations and emphasized the importance of physicians being aware of these comorbid conditions for better evaluation and management of AA patients. The document did not provide the number of people in the study, which is important for assessing the strength of the study.

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research Increased Prevalence of Vitamin D Deficiency in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis

48 citations , May 2018 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

People with alopecia areata often have lower vitamin D levels and are more likely to be deficient in it.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , January 2018 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm

29 citations , December 2017 in “International Journal of Dermatology”

People with alopecia areata often have lower vitamin D levels, which are linked to more severe and longer-lasting hair loss, but vitamin D receptor levels in the skin don't show the same pattern and don't predict treatment success.

research Management of Alopecia Areata: Updates and Algorithmic Approach

47 citations , June 2017 in “Journal of dermatology”

New treatments for alopecia areata show promise, but no cure exists and responses to treatments vary.

research Alopecia Areata and Vitamin D: Is There Any Association?

1 citations , June 2017 in “Journal of The American Academy of Dermatology”

People with alopecia areata often have lower vitamin D levels than healthy people.

research Alopecia Areata in the Elderly: A 10-Year Retrospective Study

9 citations , January 2015 in “Annals of dermatology/Annals of Dermatology”

Alopecia areata in elderly people is usually mild and responds well to treatment.

research Vitamin D Deficiency in Alopecia Areata

105 citations , June 2014 in “British journal of dermatology/British journal of dermatology, Supplement”

research Audiological Abnormalities in Patients with Alopecia Areata

11 citations , September 2013 in “Journal of The European Academy of Dermatology and Venereology”

People with alopecia areata may be more likely to have a certain type of hearing loss.

research Reduced Level of 25-Hydroxyvitamin D in Chronic/Relapsing Alopecia Areata

40 citations , April 2013 in “Dermato-endocrinology”

People with chronic Alopecia Areata often have lower vitamin D levels.

research Insulin Resistance Is Increased in Alopecia Areata Patients

18 citations , August 2012 in “Cutaneous and Ocular Toxicology”

People with alopecia areata have higher insulin resistance.

research Late-Onset Alopecia Areata: A Retrospective Study of 73 Patients from Taiwan

21 citations , February 2012 in “Journal of the European Academy of Dermatology and Venereology”

Late-onset alopecia areata in Taiwanese patients is more common in women, usually starts at age 57, often involves less than 10% hair loss, and may have a minimal link to thyroid issues.

research Alopecia Areata Update

391 citations , February 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss

207 citations , May 2006 in “Journal of The American Academy of Dermatology”

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

research Decreased Serum Ferritin Is Associated With Alopecia in Women

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Low iron levels may be linked to some types of hair loss in women.

1 / 1 results

research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.