Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways

April 2017 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Alice Kwon, E. Wang, Gina M. DeStefano, Anjni Patel, Esther Drill, Sivan Harel, C. Cera, Masoud Tavazoie, Angela M. Christiano

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alopecia areata miRNAs immune-regulatory pathways antigen processing IFNg signaling T cell costimulation apoptosis chemotaxis miR-30b miR-365 miR-100 miR-155 miR-1 miR-705 TAP2 CTLA4 ICOS BAK CXCL11 AA immune pathways cell signaling cell death cell movement

Studysummary This study found that dysregulated microRNA expression in mice may be linked to aberrant gene activity that contributes to the development of alopecia areata.

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