Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

September 2023 in “ Clinical, cosmetic and investigational dermatology ”

Jai Sing Yang, Ting-Yuan Liu, Yu‐Chia Chen, Shih‐Chang Tsai, Yu‐Jen Chiu, Chi-Chou Liao, Fuu‐Jen Tsai

alopecia areata genome-wide association study single nucleotide polymorphisms LINC02006 APC SRP19 EGFLAM LDLRAD3 immune response pathways HLA genotypes HLA-DQA1*01:02 immune cell infiltration antigen presentation Notch signaling AA GWAS SNPs HLA

TLDR Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.

This genome-wide association study (GWAS) on alopecia areata (AA) in a Taiwanese cohort of 408 AA cases and 8,167 controls identified seven significant single nucleotide polymorphisms (SNPs) in genes such as LINC02006, APC, SRP19, EGFLAM, and LDLRAD3, which are linked to immune response pathways. Additionally, four HLA genotypes, particularly HLA-DQA1*01:02, were associated with AA. These findings suggest that genetic variants related to immune cell infiltration and signaling pathways like antigen presentation and Notch signaling contribute to AA susceptibility in the Taiwanese population, enhancing the understanding of AA's genetic basis.

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Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

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