Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

    September 2023 in “ Clinical, cosmetic and investigational dermatology ”
    Jai Sing Yang, Ting-Yuan Liu, Yu‐Chia Chen … Fuu‐Jen Tsai
    Studysummary This genome-wide association study identified several genetic markers, including specific SNPs and HLA genotypes, associated with alopecia areata susceptibility in the Taiwanese population, highlighting key pathways involved in immune response and offering insights into the genetic origins of this autoimmune condition.
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    Research cited in this study 21

    1. Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review Genes · 2023
    2. The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity Journal of the European Academy of Dermatology and Venereology · 2023
    3. Anxiety, Depression, and Quality of Life in Children and Adults With Alopecia Areata: A Systematic Review and Meta-Analysis Frontiers in Medicine · 2022
    4. Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
    5. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    6. Regulation and Dysregulation of Hair Regeneration: Aiming for Clinical Application Cell Regeneration · 2022
    7. The Epidemiology of Alopecia Areata: A Population-Based Cohort Study in UK Primary Care British Journal of Dermatology · 2021
    8. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021
    9. The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
    10. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020
    11. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    12. High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
    13. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    14. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    15. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015
    16. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014
    17. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    18. Genetic Association of HLA-DQB1 and HLA-DRB1 Polymorphisms with Alopecia Areata in the Italian Population British Journal of Dermatology · 2011
    19. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    20. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    21. Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata The American Journal of Human Genetics · 2007