The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

    July 2020 in “ International Journal of Molecular Sciences ”
    Jung Eun Kim, Yu Jin Lee, Hye Ree Park, Dong Geon Lee, Kwan Jeong, Hoon Kang
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    TLDR Ruxolitinib may help treat hair loss by reducing inflammation, promoting hair growth signals, and protecting hair follicle immunity.
    The study explored the impact of ruxolitinib, a JAK1/2 inhibitor, on human dermal papilla cells (hDPCs) in the context of alopecia areata (AA). Ruxolitinib was found to maintain cell viability, activate the Wnt/ß-catenin signaling pathway, suppress DKK1 transcription, and reverse the expression of inflammatory molecules induced by interferon gamma (IFN-γ), such as caspase-1, IL-1ß, IL-15, and IL-18. Additionally, it stimulated the expression of growth factors like FGF7 and protected against the IFN-γ-induced collapse of hair-follicle immune privilege. The study concluded that ruxolitinib could potentially treat AA by modulating inflammatory changes, stimulating anagen-re-entry signals, and preserving hair-follicle immune privilege. However, the experiments had a small sample size (n = 3), suggesting that further research with larger sample sizes is necessary to validate these results.
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