TLDR The study suggests that hypothyroidism may cause alopecia areata.
This study utilized Mendelian randomization to analyze genetic data from 30,155 hypothyroidism cases and 379,986 controls, as well as 289 alopecia areata cases and 211,139 controls, to investigate the causal relationship between hypothyroidism and alopecia areata. The results indicated that genetic variants associated with hypothyroidism significantly increased the risk of developing alopecia areata, with an odds ratio (OR) of 1.40 and a 95% confidence interval (CI) of 1.12–1.75 (p = 3.03×10^−3). The study also identified key pathways and genes, such as Th1 and Th2 cell differentiation and T-cell receptor signaling, that may be involved in this relationship. The findings suggest that hypothyroidism may be a causal determinant of alopecia areata, providing a potential target for developing more effective treatments for the condition.
2 citations,
January 2023 in “Journal of Clinical Medicine” People with hair loss conditions may also have thyroid disorders, but more research is needed to understand the connection.
16 citations,
January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
82 citations,
March 2016 in “Autoimmunity reviews” Animal models have helped understand hair loss from alopecia areata and find new treatments.
162 citations,
October 2014 in “Autoimmunity reviews” Alopecia areata is caused by the immune system attacking hair follicles.
72 citations,
October 2009 in “The FASEB journal” TRH stimulates human hair growth and extends the hair growth phase.
January 2022 in “Medical research archives” Taking vitamin D might improve life for MS patients and reduce skin side effects from alemtuzumab treatment.
5 citations,
May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
August 2024 in “Clinical Cosmetic and Investigational Dermatology” Hypothyroidism may cause certain types of hair loss.
March 2024 in “Frontiers in Endocrinology” The study found that alopecia areata and hypothyroidism increase the risk of each other, but androgenetic alopecia and hypothyroidism do not.
4 citations,
January 2023 in “Frontiers in Immunology” Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.
