Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study

    August 2024 in “ Clinical Cosmetic and Investigational Dermatology ”
    Gongjie Zhang, Xinlyu Huang, Hanlin Li … Fang Liu
    Studysummary This study investigates the potential causal relationship between hypothyroidism and hair loss conditions like alopecia areata and androgenetic alopecia, noting that previous studies have reported inconsistent findings. Results are not yet detailed.
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    Research cited in this study 23

    1. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    2. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    3. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    4. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    5. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    6. Association of Androgenetic Alopecia With Mortality From Diabetes Mellitus and Heart Disease JAMA Dermatology · 2013
    7. Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2013
    8. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    9. Genetic Association of HLA-DQB1 and HLA-DRB1 Polymorphisms with Alopecia Areata in the Italian Population British Journal of Dermatology · 2011
    10. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    11. Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study Journal of The American Academy of Dermatology · 2010
    12. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    13. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    14. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    15. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    16. Association of Androgenetic Alopecia and Hypertension PubMed · 2007
    17. Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata Journal of Investigative Dermatology · 2007
    18. Obesity and Low-Grade Inflammation Among Young Finnish Men With Early-Onset Alopecia Dermatology · 2007
    19. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    20. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    21. Early Androgenetic Alopecia as a Marker of Insulin Resistance The Lancet · 2000
    22. The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature British Journal of Dermatology · 1999
    23. The Risk of Coronary Heart Disease in Men with Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 1999

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    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019