Association Between Non-Scarring Alopecia and Hypothyroidism: A Bidirectional Two-Sample Mendelian Randomization Study

    March 2024 in “ Frontiers in Endocrinology ”
    Jiankang Yang, Zhenlai Zhu, Chen Zhang … Meng Fang
    Studysummary In this study, a bidirectional Mendelian randomization analysis found a causal link between alopecia areata and hypothyroidism, indicating that each condition may influence the other, while no similar relationship was observed between androgenetic alopecia and hypothyroidism.
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    Research cited in this study 12

    1. Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia Pharmaceutics · 2022
    2. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
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    4. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    5. Nonscarring Diffuse Hair Loss in Women: A Clinico-Etiological Study from a Tertiary Care Center in North-West India Journal of Cosmetic Dermatology · 2018
    6. Clinical, Trichoscopic, and Histopathologic Characteristics of Patients with Alopecia and Hypothyroidism: An Observational Study Journal of The American Academy of Dermatology · 2018
    7. Screening Guidelines for Thyroid Function in Children With Alopecia Areata JAMA dermatology · 2017
    8. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    9. Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata The Journal of Clinical Endocrinology & Metabolism · 2015
    10. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    11. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents British Journal of Dermatology · 2010
    12. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010