Clinical, Trichoscopic, and Histopathologic Characteristics of Patients with Alopecia and Hypothyroidism: An Observational Study
May 2018
in “
Journal of The American Academy of Dermatology
”
alopecia hypothyroidism bi-parietal involvement vertex superior occipital region diffuse alopecia trichoscopic examination perifollicular scaling hair shaft diameter single follicular units terminal/vellus ratio follicular miniaturization telogen effluvium diffuse thinning miniaturization telogen count hair loss thyroid-related hair loss scalp regions hair thinning hair examination scalp scaling hair thickness hair follicles hair ratio hair miniaturization hair shedding hair growth phase
Studysummary This study examined 15 female patients with hypothyroidism to investigate the characterization of their alopecia and ruled out other causes, using medical histories, and clinical, trichoscopic, and histologic findings. Our plain-language summary of this paper — not a Tressless recommendation.
The observational study, conducted on 15 female patients with hypothyroidism, found that alopecia associated with the condition often presents with bi-parietal involvement (80%), extension to the vertex and superior occipital region (33.3%), and diffuse alopecia (20%). Trichoscopic examination revealed perifollicular scaling in 93.3% of patients, decreased hair shaft diameter in 86.6%, and single follicular units in 53.3%. Histologically, an average of 31 hairs were found per field, with a decreased terminal/vellus ratio in 86.6% of cases, indicating follicular miniaturization rather than histologic telogen effluvium. The study suggests that alopecia in hypothyroidism patients is characterized by diffuse thinning, miniaturization, and a normal telogen count, and should be considered in differential diagnosis for alopecia. The study's conclusions are limited by its small sample size and observational design.
