Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of Dermal Papilla in Androgenetic Alopecia

    June 2024 in “ Research Square (Research Square) ”
    Xiaomin Liu, Maijiayi Ye, G. -Q. Tao … Zhiqi Hu

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study identified a network of interactions between miRNAs and mRNAs that involve key signaling pathways, suggesting new insights into the mechanisms behind androgenetic alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 30

    1. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    2. Identification of Functional Patterns of Androgenetic Alopecia Using Transcriptome Profiling in Distinct Locations of Hair Follicles Journal of Investigative Dermatology · 2017
    3. Genomewide Differential Expression Profiling of Long Non-Coding RNAs in Androgenetic Alopecia in a Chinese Male Population Journal of The European Academy of Dermatology and Venereology · 2017
    4. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    5. A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia Genomics · 2017
    6. Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression British Journal of Dermatology · 2016
    7. Apoptosis in Follicles of Individuals with Female Pattern Hair Loss Is Associated with Perifollicular Microinflammation International Journal of Cosmetic Science · 2016
    8. Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22 PLOS Genetics · 2015
    9. MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway Journal of Cell Biology · 2014
    10. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    11. Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells Journal of Biochemistry and Molecular Biology · 2013
    12. Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles Journal of Dermatological Science · 2013
    13. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    14. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    15. Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia Dermatologic Surgery · 2012
    16. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    17. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    18. Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method British Journal of Dermatology · 2011
    19. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    20. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    21. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    22. Proliferation, DNA Repair, and Apoptosis in Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2008
    23. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    24. Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia Biological & Pharmaceutical Bulletin · 2006
    25. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    26. Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis Journal of Dermatological Science · 2004
    27. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    28. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    29. An Investigation of Apoptosis in Androgenetic Alopecia American Journal of Dermatopathology · 2002
    30. Inflammatory Perifollicular Fibrosis And Alopecia International Journal of Dermatology · 1998

    Related research 7

    1. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    2. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    3. Effect of Orostachys Iwarenge Hara on the Proliferation of Dermal Papilla Cells Journal of Medicine and Life Science · 2010
    4. Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin Archives of Dermatological Research · 2006
    5. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    6. Experimental Approaches for the Reconstitution of Hair In Vitro Skin Pharmacology and Physiology · 1994
    7. Co-Culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix The Journal of Dermatology · 1990