Integrated miRNA and mRNA Analysis Provides New Insight into Mechanism of Dermal Papilla in Androgenetic Alopecia

June 2024 in “ Research Square (Research Square) ”

Xiaomin Liu, Maijiayi Ye, G. -Q. Tao, Xiaoqing Sun, Teng Zuo, Wei Wu, Jinghui Jin, Zhiqi Hu

androgenetic alopecia AGA dermal papilla cells miRNA mRNA MAPK Ras apoptosis miR-125b miR-106a miR-221 cell cycle hair follicle miniaturization androgenic alopecia hair loss hair follicle shrinkage

TLDR Increased cell death and reduced cell growth in hair follicles contribute to baldness.

This study explores the molecular mechanisms of androgenetic alopecia (AGA) by examining miRNA and mRNA interactions in dermal papilla cells from balding and non-balding hair follicles. Researchers identified 107 differentially expressed genes and constructed a miRNA-mRNA interaction network, highlighting 10 hub genes involved in key signaling pathways such as MAPK, Ras, and apoptosis. Key miRNAs like miR-125b, miR-106a, and miR-221 were found to regulate genes associated with cell cycle and apoptosis. The findings suggest that increased apoptosis and impaired cell growth in dermal papilla cells contribute to hair follicle miniaturization in AGA, providing new insights into its molecular mechanisms and potential therapeutic targets, though further large-scale experiments are needed to confirm these results.

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