Identification of Blood MicroRNA Alterations in Patients With Severe Active Alopecia Areata

    April 2019 in “ Journal of Cellular Biochemistry ”
    Yuan Sheng, Shaohua Qi, Ruiming Hu, Jun Zhao, Wenlong Rui, Ying Miao, Jingwen Ma, Qinping Yang
    Image of study
    TLDR Certain blood miRNAs are linked to severe alopecia areata and could lead to new treatments.
    In 2019, researchers from the Department of Dermatology at Huashan Hospital, Fudan University, Shanghai, China, conducted a study to explore blood microRNA (miRNA) alterations in patients with severe active alopecia areata (AA). Using an Agilent microarray that covers 2549 human miRNAs, they identified 36 significantly differentially expressed miRNAs in severe active AA patients. The miRNA target gene prediction and functional annotation analysis showed significant enrichment in several pathways including the ribosome, cancer, cell cycle, insulin signaling, transforming growth factor-β signaling, and p53 signaling pathways. The study concluded that blood dysregulated miRNAs are potentially associated with severe active AA and could function synergistically. These miRNAs might be promising targets for the development of novel treatments for AA in the future.
    Discuss this study in the Community →

    Research cited in this study

    22 / 22 results

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 4 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 1 year ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Similar Research

    5 / 1000+ results