Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

May 2015 in “ Molecular Medicine Reports ”

Kyung Mi Lim, Sungkwan An, Ok-Kyu Lee, Myung J. Lee, Jeong Pyo Lee, Kwang-Sik Lee, Ghang Tai Lee, Kun Kook Lee, Seunghee Bae

troxerutin human dermal papilla cells oxidative stress hydrogen peroxide reactive oxygen species senescence-associated β-galactosidase microRNA apoptosis cell proliferation alopecia HDP cells H₂O₂ ROS miRNA

Studysummary This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on spandidos-publications.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

research Oxidative Stress in Alopecia Areata: A Case-Control Study

62 citations , July 2013 in “American Journal of Clinical Dermatology”

This study found that alopecia areata patients had higher oxidative stress and lipid peroxidation levels than healthy controls, suggesting potential involvement in the disease's pathogenesis.

research Hydrogen Peroxide and Monoethanolamine Are the Key Causative Ingredients for Hair Dye-Induced Dermatitis and Hair Loss

34 citations , January 2012 in “Journal of Dermatological Science”

In this mouse study, researchers found that hydrogen peroxide and monoethanolamine in hair dyes may be key contributors to dermatitis and hair loss due to oxidative stress.

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

research Oxidative Stress in Aging of Hair

126 citations , January 2009 in “International Journal of Trichology”

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.

research Is Androgenetic Alopecia a Photoaggravated Dermatosis?

62 citations , January 2003 in “Dermatology”

This review suggests that androgenetic alopecia may be exacerbated by exposure to ultraviolet radiation and proposes considering it as a photoaggravated condition requiring photoprotection.

research Lipid Peroxides Induce Early Onset of Catagen Phase in Murine Hair Cycles

49 citations , January 1998 in “International Journal of Molecular Medicine”

In this study, lipid peroxides were found to induce apoptosis in hair follicle cells and advance the catagen phase in mice, suggesting a potential mechanism for alopecia development.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations , January 1998 in “Journal of Endocrinology”

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.

research Telogen Alopecia Induced by UV Rays

30 citations , November 1996 in “Archives of Dermatology”

This report describes cases of increased hair loss and scalp sunburns in patients using 3% minoxidil and 0.01% tretinoin, suggesting caution with tretinoin use on sunny days.