TLDR Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.
The study explored the effects of troxerutin, a flavonoid derivative, on human dermal papilla cells under oxidative stress from hydrogen peroxide (H₂O₂). Troxerutin pretreatment significantly reduced H₂O₂-induced cytotoxicity, cell death, and reactive oxygen species (ROS) production. It also decreased the number of cells in the sub-G1 phase and inhibited senescence-associated β-galactosidase activity. MicroRNA (miRNA) analysis revealed 24 differentially expressed miRNAs, which are implicated in various biological functions and signaling pathways related to aging, skin development, apoptosis, and cell proliferation. The study concluded that troxerutin has potential as a protective agent against oxidative stress in HDP cells and may be beneficial for treating hair loss conditions like alopecia. The experiments were conducted in triplicate, and statistical significance was indicated by P<0.05. However, the specific number of cells or participants used in the study was not mentioned in the summary.
56 citations,
September 2013 in “Journal of Biochemistry and Molecular Biology” Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.
62 citations,
July 2013 in “American Journal of Clinical Dermatology” Alopecia areata patients have higher oxidative stress and lower antioxidant levels.
34 citations,
January 2012 in “Journal of Dermatological Science” Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.
52 citations,
May 2011 in “APOPTOSIS” Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.
126 citations,
January 2009 in “International Journal of Trichology” Oxidative stress contributes to hair graying and loss as we age.
62 citations,
January 2003 in “Dermatology” Sunlight worsens hair loss; protect scalp.
227 citations,
January 1998 in “Journal of Endocrinology” Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
30 citations,
November 1996 in “Archives of Dermatology” UV rays can cause a type of hair loss known as telogen alopecia.
July 2024 in “International Journal of Molecular Sciences” Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.
76 citations,
August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
Natural products may help treat hair loss by promoting hair growth with fewer side effects.
3 citations,
January 2018 in “Biomedical dermatology” Green tea extract helps prevent cell death and supports cell survival in hair cells exposed to a chemotherapy drug.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
