Hydroxytyrosol Prevents Dermal Papilla Cells Inflammation Under Oxidative Stress by Inducing Autophagy

July 2019 in “ Journal of Biochemical and Molecular Toxicology ”

Qian Chen, Tao Sun, Jin Wang, Jingyi Jia, Yanhua Yi, Yuxin Chen, Yong Miao, Zhiqi Hu

Hydroxytyrosol oxidative stress dermal papilla cells autophagy reactive oxygen species apoptotic markers inflammation hair growth factors alopecia HT ROS

Studysummary In this study on rat dermal papilla cells, hydroxytyrosol, an antioxidant found in olive oil, was reported to protect against oxidative stress, reduce inflammation, and enhance hair growth factors, suggesting its potential to prevent hair loss.

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In 2019, a study was conducted to explore the potential protective actions of Hydroxytyrosol (HT), a primary phenolic antioxidant in olive oil, against oxidative stress in rat dermal papilla cells. The study found that HT significantly reduced intracellular reactive oxygen species level, apoptotic markers, and inflammation induced by oxidative stress, and enhanced cell survival by regulating autophagy. Additionally, HT enhanced the secretion of hair growth factors in the anti-inflammation process. These results suggested that HT has a significant protective ability against oxidative stress and could potentially be used to prevent alopecia.

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