Effects of Nannochloropsis Salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth

    Ming Ying, Jialin Zhou, Zuye Zeng, Shuangfei Li, Xuewei Yang
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    TLDR Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.
    The study investigated the effects of Nannochloropsis salina fermented oil (NSO) on human dermal papilla cells (DPCs) and hair growth. NSO, rich in eicosapentaenoic acid, palmitic acid, and linoleic acid, significantly promoted DPC proliferation, reduced oxidative damage, and upregulated antioxidant-related genes. In vivo experiments on C57BL/6 mice showed that topical NSO application increased hair length and weight, and histological analysis confirmed enhanced hair follicle number, depth, and thickness. These findings suggest NSO as a potential natural treatment for hair loss by promoting hair growth and mitigating oxidative stress.
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