Effects of Nannochloropsis Salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth

    Ming Ying, Jialin Zhou, Zuye Zeng, Shuangfei Li, Xuewei Yang
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    TLDR Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.
    The study investigated the effects of Nannochloropsis salina fermented oil (NSO) on human dermal papilla cells (DPC) and hair growth. GC/MS analysis identified eicosapentaenoic acid, palmitic acid, and linoleic acid as the main components of NSO. NSO was found to promote DPC proliferation and reduce oxidative stress. RNA-seq and qRT-PCR confirmed changes in gene expression in cells treated with NSO and minoxidil. Additionally, NSO positively influenced hair length, weight, the number and depth of hair follicles, and dermal thickness, suggesting its potential as a treatment for hair loss.
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