Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

November 2021 in “ Journal of The American Academy of Dermatology ”

Anthony Moussa, Ahmed Kazmi, Laita Bokhari, Rodney Sinclair

bicalutamide minoxidil hypertrichosis female pattern hair loss antiandrogen therapy Rogaine

TLDR Bicalutamide may reduce unwanted hair growth caused by minoxidil in women with hair loss.

The document discusses a retrospective review involving 35 patients with female pattern hair loss (FPHL) treated with low-dose systemic minoxidil and antiandrogen therapy, specifically bicalutamide. The study highlights that while minoxidil is effective and generally safe, it can cause hypertrichosis in up to 24% of patients. The review suggests that bicalutamide may improve minoxidil-induced hypertrichosis, offering a potential solution for managing this side effect in FPHL treatment.

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Research cited in this study

4 / 4 results

research Safety of Low-Dose Oral Minoxidil Treatment for Hair Loss: A Systematic Review and Pooled Analysis of Individual Patient Data

14 citations, August 2020 in “Dermatologic Therapy”

Low-dose oral minoxidil is a safe treatment for hair loss, with the main side effect being excessive hair growth. Other side effects like foot swelling, low blood pressure when standing, and heart rate changes are rare.

research Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss

8 citations, April 2020 in “Journal of The American Academy of Dermatology”

Bicalutamide may be a promising alternative treatment for female pattern hair loss.

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

80 citations, December 2017 in “International Journal of Dermatology”

Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.

research Minoxidil May Suppress Androgen Receptor-Related Functions

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Minoxidil can reduce functions related to androgen receptors.

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research Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

4 citations, November 2021 in “Journal of The American Academy of Dermatology”

Bicalutamide may reduce unwanted hair growth caused by minoxidil in women with hair loss.

research Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss

7 citations, September 2020 in “Journal of The American Academy of Dermatology”

Low-dose oral minoxidil for hair loss can cause mild excessive hair growth, usually appearing within the first 3 months, but it can be managed by adjusting the dose or removing the unwanted hair, with most people not needing to stop the treatment.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Clinical Updates in Hair

19 citations, January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations, February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

research Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up

34 citations, January 1987 in “Dermatology”

Topical minoxidil effectively and safely treats extensive alopecia areata but doesn't change its course.

Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients

Research cited in this study

research Safety of Low-Dose Oral Minoxidil Treatment for Hair Loss: A Systematic Review and Pooled Analysis of Individual Patient Data

research Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

research Minoxidil May Suppress Androgen Receptor-Related Functions

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