Identification of MicroRNAs Involved in Growth Arrest and Cell Death in Hydrogen Peroxide-Treated Human Dermal Papilla Cells

April 2014 in “ Molecular Medicine Reports ”

Ok-Yeon Kim, Hwa Jun, Kyu Joong Ahn, In‐Sook An, Sungkwan An, Seunghee Bae

microRNAs miRNAs human dermal papilla cells hydrogen peroxide H2O2 cell growth arrest apoptosis gene ontology hair follicle disorders

TLDR Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

The study identified 68 differentially expressed miRNAs (62 upregulated, 6 downregulated) in human dermal papilla cells treated with hydrogen peroxide (H2O2). These miRNAs were linked to 14,316 putative target genes, which were associated with cell growth arrest and apoptosis. Gene ontology analysis confirmed that these miRNAs played significant roles in H2O2-induced cellular responses. The findings suggested that targeting these miRNAs could provide new therapeutic strategies for treating H2O2-induced hair follicle disorders.

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