Comparative Regenerative Mechanisms Across Different Mammalian Tissues

The review article explored the limited regenerative abilities in mammals compared to other metazoans, focusing on the molecular mechanisms underlying tissue regeneration. It highlighted factors constraining regeneration, such as immune responses, extracellular matrix (ECM) composition, age, and injury type. Despite these constraints, progress was made in understanding key molecular mechanisms, like the Hippo pathway in cardiac regeneration, which could serve as therapeutic targets. The study emphasized the importance of comparing regenerative mechanisms across species to enhance mammalian regenerative responses. It also discussed the role of the ECM in tissue regeneration, the influence of immune responses, and the regenerative capacities of the heart, liver, pancreas, intestine, and skin, noting the complexity and tissue-specific nature of these processes.