132 citations
,
June 2016 in “Cell and Tissue Research” This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.
128 citations
,
August 2015 in “Cell Stem Cell” The researchers reported that dsRNA from damaged skin activates TLR3, promoting hair follicle regeneration, while TLR3-deficient animals fail to initiate this process, suggesting potential therapeutic approaches for hair neogenesis.
66 citations
,
July 2015 in “Journal of Molecular Biology” This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.
236 citations
,
April 2015 in “Cell” This study found that patterned hair plucking in mice triggers a collective regeneration response in nearby unplucked hair follicles via a quorum sensing mechanism involving immune signaling.
46 citations
,
March 2015 in “Regeneration” This review revisits the mechanisms of wound induced hair follicle neogenesis in mice and concludes that the process involves canonical WNT signaling activated by Fgf9 from γδ T cells, but more research is needed to fully understand its cellular bases.
359 citations
,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” This article reviews the role of skin appendages in wound healing and appendage regeneration, discussing cellular and molecular mechanisms but reports no new experimental findings.
51 citations
,
August 2013 in “The Journal of experimental medicine/The journal of experimental medicine” This study found that Wnt secretion is important for maintaining skin homeostasis in mice, as Evi-deficient mice developed psoriasis-like skin lesions and had an imbalance in immune cell populations.
237 citations
,
June 2013 in “Nature Medicine” This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.
55 citations
,
February 2013 in “The Anatomical Record” This study found that the mouse nail unit structurally resembles the human nail unit, indicating it could be useful for researching nail diseases and biology.
418 citations
,
September 2012 in “Nature” This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.
139 citations
,
October 2005 in “Journal of Investigative Dermatology” This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.
41 citations
,
September 2005 in “Wound Repair and Regeneration” This study found that hydrogen peroxide interfered with scarless healing in a murine fetal wound repair model, potentially by inducing transforming growth factor-beta1, which may contribute to increased fibrosis.