Macrophages and Fibroblasts During Inflammation and Tissue Repair in Models of Organ Regeneration

This review summarized the roles of macrophages and fibroblastic cells in inflammation and tissue repair following organ injury, highlighting their activation states that influence outcomes from regeneration to fibrosis. It discussed mammalian models of organ regeneration, such as skin, hair follicles, and digit tips, emphasizing the involvement of local immune cells. Additionally, it covered early amphibian limb and tail regeneration, noting the transition from inflammation to regeneration initiated by fibroblasts and gene expression for limb patterning.