Diverse Mechanisms for Endogenous Regeneration and Repair in Mammalian Organs

    May 2018 in “ Nature ”
    J. Michael Wells, Fiona M. Watt
    Studysummary Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.
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    Research cited in this study 15

    1. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    2. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    3. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    4. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    5. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    6. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016
    7. Epigenetic Control of Adult Stem Cell Function Nature Reviews Molecular Cell Biology · 2016
    8. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    9. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    10. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity Cell reports · 2016
    11. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    12. Modulating the Stem Cell Niche for Tissue Regeneration Nature Biotechnology · 2014
    13. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    14. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    15. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007