TLDR The symposium concluded that understanding how different species repair tissue and how this changes with age can help advance regenerative medicine.
The symposium discussed the variability in regenerative capacity among species and its decline with aging, with implications for regenerative medicine. Highlights included Claudia Angeli's work on spinal cord injury recovery, Ashley Seifert's research on the African spiny mouse's scarless skin healing, Sandra Rieger's identification of hydrogen peroxide's role in wound repair, and Vicki Losick's discovery of polyploidy in fruit fly wound repair. Studies on C. elegans, long-lived clams, and the African turquoise killifish provided insights into maintaining cellular integrity with age. Phil Newmark's research on schistosomes' stem cells, muscle stem cells' response to injury, the role of germ granules in C. elegans, and the regulation of hair follicle stem cells by the dermal papilla were also discussed. Cardiac repair research identified Hopx in myogenesis and suggested CBSCs for heart repair. The importance of the immune system in regeneration was emphasized, and comparative biology was proposed as a means to understand tissue repair mechanisms.
31 citations,
May 2015 in “Stem Cell Reports” Stem cells and their surrounding environment in hair follicles work closely together, affecting hair growth and having implications for cancer and tissue regeneration.
[object Object] 
418 citations,
September 2012 in “Nature” African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.
143 citations,
September 2008 in “Experimental gerontology” Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
17 citations,
December 2019 in “Stem Cells International” Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
[object Object] 5 citations,
January 2021 in “Frontiers in cell and developmental biology” Skin cysts might help advance stem cell treatments to repair skin.
205 citations,
August 2007 in “Experimental Cell Research” Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.
1 citations,
November 2014 in “Elsevier eBooks” Future research should focus on making bioengineered skin that completely restores all skin functions.
