Hydrogen Peroxide (H2O2) Suppresses Hair Growth Through Downregulation of Beta-Catenin

    September 2017 in “ Journal of Dermatological Science ”
    Jungyoon Ohn, So Jeong Kim, Soon-Jin Choi, Yun Seon Choe, Oh Sang Kwon, Kyu Han Kim
    TLDR Hydrogen peroxide in hair dye can cause hair loss.
    The study investigated the effects of hydrogen peroxide (H2O2) on hair growth, focusing on the GSK-3β/β-catenin signaling pathway in human hair follicles and dermal papilla cells. It was found that H2O2, a common ingredient in hair dyes, induced oxidative stress that led to hair loss by downregulating β-catenin, a crucial component in hair follicle morphogenesis and regeneration. This research highlighted the cytotoxic effects of H2O2, which, despite its role in modulating signaling pathways, contributed to hair dye-induced hair loss.
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