Hydrogen Peroxide (H2O2) Suppresses Hair Growth Through Downregulation of Beta-Catenin

September 2017 in “ Journal of Dermatological Science ”

Jungyoon Ohn, So Jeong Kim, Soon-Jin Choi, Yun Seon Choe, Oh Sang Kwon, Kyu Han Kim

hydrogen peroxide H2O2 β-catenin GSK-3β oxidative stress hair follicle dermal papilla cells hair morphogenesis hair regeneration cytotoxic effects hair dye

TLDR Hydrogen peroxide in hair dye can cause hair loss.

The study investigated the effects of hydrogen peroxide (H2O2) on hair growth, focusing on the GSK-3β/β-catenin signaling pathway in human hair follicles and dermal papilla cells. It was found that H2O2, a common ingredient in hair dyes, induced oxidative stress that led to hair loss by downregulating β-catenin, a crucial component in hair follicle morphogenesis and regeneration. This research highlighted the cytotoxic effects of H2O2, which, despite its role in modulating signaling pathways, contributed to hair dye-induced hair loss.

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Research cited in this study

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research Identification of MicroRNAs Involved in Growth Arrest and Cell Death in Hydrogen Peroxide-Treated Human Dermal Papilla Cells

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Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

research Hydrogen Peroxide and Monoethanolamine Are the Key Causative Ingredients for Hair Dye-Induced Dermatitis and Hair Loss

34 citations, January 2012 in “Journal of Dermatological Science”

Hydrogen peroxide and monoethanolamine in hair dye can cause dermatitis and hair loss.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro

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Hydrogen Peroxide (H2O2) Suppresses Hair Growth Through Downregulation of Beta-Catenin

Research cited in this study

research Identification of MicroRNAs Involved in Growth Arrest and Cell Death in Hydrogen Peroxide-Treated Human Dermal Papilla Cells

research Hydrogen Peroxide and Monoethanolamine Are the Key Causative Ingredients for Hair Dye-Induced Dermatitis and Hair Loss

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

research Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro

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research Temporal-Spatial Activation of Wnt-Signaling Within Type 1 and Type 2 Immunity During Wound Healing