EZH2-Mediated Inhibition of MicroRNA-22 Promotes Differentiation of Hair Follicle Stem Cells by Elevating STK40 Expression

    July 2020 in “ Aging ”
    Bingjie Cai, Min Li, Yunpeng Zheng … Guangwen Yin
    Studysummary This study found that the enhancer of zeste homolog 2 (EZH2) may promote hair growth by increasing STK40 expression and facilitating hair follicle stem cell proliferation and differentiation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on aging-us.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Immunohistochemical Dissection of Cystic Panfolliculoma Focusing on the Expression of Multiple Hair Follicle Lineage Markers with an Insight into the Pathogenesis Journal of Cutaneous Pathology · 2017
    2. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    3. Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22 PLOS Genetics · 2015
    4. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    5. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    6. MicroRNA/mRNA Regulatory Networks in the Control of Skin Development and Regeneration Cell Cycle · 2012
    7. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    8. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011