12 citations
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July 2020 in “Aging” This study found that the enhancer of zeste homolog 2 (EZH2) may promote hair growth by increasing STK40 expression and facilitating hair follicle stem cell proliferation and differentiation.
July 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” In this study, researchers identified the miR-22-3p/CLIC4 signaling pathway as a key regulator in hair follicle miniaturization among androgenetic alopecia models, suggesting that targeting CLIC4-mediated sonic hedgehog pathway disruption may offer new therapeutic strategies for AGA treatment.
52 citations
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May 2015 in “PLOS Genetics” This study found that the microRNA miR-22 is a key regulator of the hair cycle, influencing hair loss by promoting the transition from growth to rest phases and repressing keratinocyte differentiation.
29 citations
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October 2011 in “British Journal of Dermatology” This study found that four microRNAs, which were significantly upregulated in balding hair follicle papilla cells, could play a role in the development of male pattern baldness.
This study found that miR-22 regulates hair loss in mice by causing premature regression of hair follicles and suggests the importance of the microRNA regulatory network in understanding hair cycling and loss.