The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study

    Ester Lee, Mi Soo Choi, Byong Seong Cho, Yu Jin Won, Jun Ho Lee, Soon Re Kim, Myung Hwa Kim, Jae Yong Jeon, Gyeong‐Hun Park, Hyuck Hoon Kwon, Joon Lee, Kui Young Park, Byung Cheol Park
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    TLDR Adipose stem cell-derived exosomes are safe and effective for hair regrowth in AGA patients.
    The study investigates the efficacy of adipose stem cell-derived exosomes (ASC-Exosomes) in treating androgenetic alopecia (AGA), a common hair loss condition. The research involved both preclinical and clinical evaluations, including tests on human hair follicle dermal papilla cells and a clinical trial with 30 participants over 24 weeks. Results showed that ASC-Exosomes enhance hair follicle cell proliferation and activate the Wnt/β-catenin pathway, which is crucial for hair growth. Participants experienced a significant increase in hair density, improved photographic assessments, and reported high satisfaction levels, with no severe adverse reactions. The study concludes that ASC-Exosomes present a promising, safe, and effective treatment alternative for AGA.
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