The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study

    August 2024 in “ International Journal of Dermatology ”
    Ester Lee, Mi Soo Choi, Byong Seong Cho … Byung Cheol Park
    Studysummary This study found that treating patients with androgenetic alopecia using exosomes from adipose tissue stem cells over 24 weeks significantly increased hair density and patient satisfaction without severe adverse effects, suggesting a promising alternative treatment for hair loss.
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    Research cited in this study 19

    1. Exosomes and Hair Restoration Advances in Cosmetic Surgery · 2023
    2. Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients Journal of cosmetic dermatology · 2022
    3. Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study Aesthetic surgery journal · 2022
    4. The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics Pharmacological research · 2021
    5. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    6. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    7. Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons Aesthetic Plastic Surgery · 2018
    8. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    9. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women PubMed · 2018
    10. Human Mesenchymal Stem Cell-Derived Conditioned Media for Hair Regeneration Applications PubMed · 2017
    11. Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells Current stem cell research & therapy · 2017
    12. Activin A-Induced Signaling Controls Hair Follicle Neogenesis Experimental Dermatology · 2016
    13. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    14. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011
    15. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    16. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    17. A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification Journal of The American Academy of Dermatology · 2007
    18. Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension Journal of Clinical Hypertension · 2004
    19. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004

    Related research 2

    1. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    2. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001