The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study

    Ester Lee, Mi Soo Choi, Byong Seong Cho, Yu Jin Won, Jun Ho Lee, Soon Re Kim, Myung Hwa Kim, Jae Yong Jeon, Gyeong‐Hun Park, Hyuck Hoon Kwon, Joon Lee, Kui Young Park, Byung Cheol Park
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    TLDR Adipose stem cell-derived exosomes are safe and effective for hair regrowth in AGA patients.
    This study investigated the efficacy of adipose stem cell-derived exosomes (ASC-Exosomes) in treating androgenetic alopecia (AGA). In vitro tests showed that ASC-Exosomes increased the proliferation of human hair follicle dermal papilla cells and upregulated hair growth-related genes, activating the Wnt/β-catenin pathway. In a clinical trial with 30 AGA patients treated over 24 weeks, there was a significant increase in hair density, improved photographic assessments, and high subjective satisfaction, with no severe adverse reactions. The findings suggest that ASC-Exosomes are a safe and effective treatment for hair regeneration in AGA patients.
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