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Glossary Regulatory Network

interactions controlling gene expression within a cell

A Regulatory Network, often referred to as a Gene Regulatory Network (GRN), is a complex system of interactions between genes, proteins, and other molecules that control the expression levels of genes within a cell. These networks are crucial for determining how cells respond to various signals and environmental conditions, ultimately influencing processes like development, differentiation, and disease.

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research LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

25 citations , August 2017 in “Animal Biotechnology”

This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.

research Regulatory network of ginsenoside biosynthesis under Ro stress in the hairy roots of Panax ginseng revealed by RNA sequencing

5 citations , October 2022 in “Frontiers in bioengineering and biotechnology”

Ro stress hindered ginseng root growth and ginsenoside production, but increased certain hormones and affected gene regulation related to plant growth and stress responses.

research Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

3 citations , May 2023 in “Precision clinical medicine”

This study analyzed gene expression data to identify key genes involved in severe forms of alopecia areata, discovering four immune monitoring genes (LGR5, SHISA2, HOXC13, S100A3) with potential for early diagnosis and better understanding of the disease's biological mechanisms.

research Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

This study constructed a ceRNA regulatory network related to cashmere goat secondary hair follicle development, highlighting the role of circRNA in their morphogenesis through the ceRNA mechanism.

research RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers identified a gene regulatory network in Arabidopsis that controls root hair growth under low-temperature conditions, revealing specific transcription factors and downstream targets that contribute to this growth response despite overall plant development being halted.

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community The ANSM is trying to ban Finasteride

in Research/Science 110 upvotes 1 year ago

France is considering reviewing finasteride and dutasteride due to concerns about their safety, but a ban in the EU is unlikely due to regulatory hurdles. Many users express frustration over the potential ban, emphasizing the effectiveness of finasteride for hair loss and criticizing the influence of anecdotal evidence on public health policy.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Finasteride is save in the eu (they concluded the investigation)

in Finasteride/Dutasteride 335 upvotes 1 year ago

Finasteride and dutasteride are still available in the EU, with a warning about potential suicidal thoughts. The benefits of these treatments are deemed greater than the risks.

community Verteporfin and Microneedling

in Treatments 2 years ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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