Shh Gene Regulates Proliferation and Apoptosis of Dermal Papilla Cells in Secondary Hair Follicle Growth Cycle of Cashmere Goats

The study examines the role of the Sonic hedgehog (Shh) gene in the growth cycle of secondary hair follicles in cashmere goats, revealing that Shh expression peaks during the anagen phase and is lowest during telogen. Overexpression of Shh enhances dermal papilla cell (DPC) proliferation and reduces apoptosis, while interference with Shh has the opposite effect. The Shh gene influences the Hedgehog signaling pathway, affecting genes like Ptched, Smoothened, and Gli2, which are crucial for DPC regulation. These findings provide insights into the molecular mechanisms affecting cashmere quality and offer a theoretical basis for improving cashmere production.