Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

May 2020 in “ Research Square (Research Square) ”

Feng Yang, Zhihong Liu, Tianyu Che, Jun‐tao Guo, Yingxin Xie, Hegang Li, Zhixin Wang, Jinshan Zhao, jinquan li

dermal papilla cells hair follicle cycle single-cell RNA sequencing cell fate decisions apoptosis follicular cycles hair growth DP progenitor cells DP cells hair cycle RNA sequencing cell decisions cell death hair cycles progenitor cells

TLDR Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

Using cashmere goats as a model due to their clear hair follicle periodicity, researchers conducted single-cell RNA sequencing to investigate the role of dermal papilla (DP) cells in hair follicle cycles. They constructed a DP cell lineage differentiation trajectory, identifying key genes and signaling pathways involved in cell fate decisions. The study revealed four distinct intermediate DP cell states with specific functions: Intermediate cells 10 were crucial for cashmere growth and attachment; intermediate cells 1 played a significant role in apoptosis and shedding of secondary hair follicles; intermediate cells 0 initiated new follicular cycles and hair growth; and intermediate cells 15 were identified as DP progenitor cells. This research provides a deeper understanding of DP cell functions and their differentiation during the hair follicle cycle.

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