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    Glossary Cell Fate Decisions

    process by which cells determine their future identity and function

    Cell fate decisions refer to the process by which cells determine their future identity and function during development. This involves a series of signals and regulatory mechanisms that guide a cell to become a specific type, such as a skin cell, nerve cell, or hair follicle cell. Understanding these decisions is crucial for fields like regenerative medicine and treating conditions like alopecia, where promoting the correct cell fate can help regenerate hair follicles.

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    1. Cell fate decisions: emerging roles for metabolic signals and cell morphology EMBO Reports · 2017 · 100 citations
    2. The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Cell Metabolism · 2025
    3. Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    4. Keeping up with the neighbours: local synchronisation of cell fate decisions during development EMBO Reports · 2025
    5. Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling EMBO journal · 2021 · 5 citations
    6. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day Development · 2014 · 91 citations
    7. Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats Research Square (Research Square) · 2020
    8. 836 Applying FACS-based single cell RNA-seq to study neonatal mouse skin Journal of Investigative Dermatology · 2017
    9. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    10. Decision letter: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium 2020
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