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Glossary Cell Fate Decisions

process by which cells determine their future identity and function

Cell fate decisions refer to the process by which cells determine their future identity and function during development. This involves a series of signals and regulatory mechanisms that guide a cell to become a specific type, such as a skin cell, nerve cell, or hair follicle cell. Understanding these decisions is crucial for fields like regenerative medicine and treating conditions like alopecia, where promoting the correct cell fate can help regenerate hair follicles.

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Research

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research Cell fate decisions: emerging roles for metabolic signals and cell morphology

100 citations , November 2017 in “EMBO Reports”

This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.

research The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury

June 2025 in “Cell Metabolism”

This study found that dietary serine levels influence hair follicle stem cells' ability to balance hair regeneration and wound repair, offering insights for potential interventions to accelerate wound healing.

research Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

2 citations , July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study demonstrates that neural stem cells in the adult vertebrate brain coordinate their division decisions using delayed local feedback mechanisms, involving Notch-mediated inhibition and dispersion effects, to maintain population homeostasis.

research Keeping up with the neighbours: local synchronisation of cell fate decisions during development

December 2025 in “EMBO Reports”

This review discusses how stem and progenitor cells communicate to synchronize their differentiation responses, highlighting the challenges in identifying these mechanisms and surveying new technologies that may overcome these obstacles.

research Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling

5 citations , May 2021 in “EMBO journal”

This review discusses the role of polarity signaling in coordinating tissue mechanics, micro-environmental functions, and cell fate decisions, but it reports no new results, highlighting the need for further study in mammalian models.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community 9 Months post FUE surgery hair result. 4052 grafts, 10130 hairs transplanted

1093 upvotes 1 year ago

The individual had a hair transplant in Turkey with 4052 grafts, resulting in significant hair growth and increased confidence. They use finasteride, rosemary oil, and vitamins, and are pleased with the natural-looking results, encouraging others to consider similar treatments.

community It's sad how many guys shave because they don't know

2209 upvotes 1 year ago

Finasteride and dutasteride can prevent hair loss if used early, but they may cause side effects. Many men shave their heads because they are unaware of these treatments or avoid them due to side effects or cost.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

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