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    Glossary Cell Fate Decisions

    process by which cells determine their future identity and function

    Cell fate decisions refer to the process by which cells determine their future identity and function during development. This involves a series of signals and regulatory mechanisms that guide a cell to become a specific type, such as a skin cell, nerve cell, or hair follicle cell. Understanding these decisions is crucial for fields like regenerative medicine and treating conditions like alopecia, where promoting the correct cell fate can help regenerate hair follicles.

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    1. Cell fate decisions: emerging roles for metabolic signals and cell morphology EMBO Reports · 2017 · 100 citations
    2. The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Cell Metabolism · 2025
    3. Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    4. Keeping up with the neighbours: local synchronisation of cell fate decisions during development EMBO Reports · 2025
    5. Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling EMBO journal · 2021 · 5 citations
    6. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day Development · 2014 · 91 citations
    7. Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats Research Square (Research Square) · 2020
    8. 836 Applying FACS-based single cell RNA-seq to study neonatal mouse skin Journal of Investigative Dermatology · 2017
    9. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    10. Decision letter: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium 2020
    11. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    12. BMP signaling in the control of skin development and hair follicle growth Differentiation · 2004 · 165 citations
    13. Edar Signaling in the Control of Hair Follicle Development 2005 · 71 citations
    14. Cellular dynamics in the niche of infrequently dividing hair follicle stem cells in the mouse Mus musculus eCommons (Cornell University) · 2010
    15. 877 Small T antigen from a folliculotropic polyomavirus activates canonical Wnt/β-catenin signaling in vivo Journal of Investigative Dermatology · 2017
    16. Sox9 regulates melanocytic fate decision of adult hair follicle stem cells iScience · 2023 · 10 citations
    17. The Functions and Mechanisms of TGF‐β3 Signalling in Controlling the Fate Determinations of Various Types of Stem Cells Journal of Cellular Physiology · 2026
    18. KIF18B is a cell-type specific regulator of spindle orientation in the epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2021
    19. <i>N</i>1-acetylspermidine is a determinant of hair follicle stem cell fate Journal of Cell Science · 2021 · 17 citations
    20. Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    21. Understanding The Molecular Mechanisms Of Hair Follicle Stem Cell Quiescence And Genome Plasticity eCommons (Cornell University) · 2013
    22. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    23. 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation Journal of Investigative Dermatology · 2024
    24. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    25. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    26. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging Cell Stem Cell · 2014 · 17 citations
    27. Activin/Nodal signalling in stem cells Development · 2015 · 194 citations
    28. Unravelling a novel role for cannabidivarin in the modulation of subventricular zone postnatal neurogenesis European Journal of Pharmacology · 2023 · 7 citations
    29. RNA signaling in cellular plasticity during homeostasis and regeneration Current Opinion in Genetics & Development · 2026
    30. 876 Manipulation of stem cell divisional behavior: Selectively promoting asymmetric and symmetric keratinocyte divisions in vitro Journal of Investigative Dermatology · 2017