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Glossary Cell Microenvironment

immediate surroundings influencing cell behavior and function

The cell microenvironment, also known as the cellular microenvironment, refers to the immediate surroundings of a cell, including the extracellular matrix, neighboring cells, and various signaling molecules. This environment plays a crucial role in regulating cell behavior, function, and fate by providing biochemical and mechanical cues. Understanding the cell microenvironment is essential for fields like tissue engineering, cancer research, and regenerative medicine, as it influences processes such as cell growth, differentiation, and migration.

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Research

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research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.

research Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia

6 citations , April 2012 in “PloS one”

This study used transgenic mice to show that disrupting TGF-β signaling in K14+ progenitor cells led to increased stem cell proliferation in the tongue.

research Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity

15 citations , March 2021 in “Journal of Nanobiotechnology”

This study developed a nanoscale biomimetic matrix that effectively and stably expands human hair follicle stem cells, offering a new tool for hair follicle reconstruction research.

research Cell/Tissue Microenvironment Engineering and Monitoring in Tissue Engineering, Regenerative Medicine, and In Vitro Tissue Models

4 citations , January 2014 in “BioMed Research International”

This special issue reviews advancements in engineering cell microenvironments for tissue engineering, highlighting various studies on interventions like silk fibroin and platelet-rich plasma, but presents no new empirical findings.

research Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment

6 citations , October 2024 in “International Journal of Dermatology”

In this study, researchers conducted single-cell RNA sequencing to reveal that proinflammatory fibroblasts and vascular endothelial cells play significant roles in the immune microenvironment of keloids, suggesting potential targets for new therapeutic approaches.

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Community Join

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community The Real Reason For Hair Loss?

8 months ago

Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

8 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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Learn

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learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.
How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.
Are stem cell factor products safe for long-term scalp use? Stem cell factor products lack proven long-term safety for scalp use.
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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Thymosin Beta 4

learn Beta Polypeptide

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