Search
for

    Glossary Cancer-Associated Fibroblasts

    specialized cells in tumors that support cancer growth and spread

    Cancer-Associated Fibroblasts (CAFs) are specialized cells found within the tumor microenvironment that play a crucial role in cancer progression. They support tumor growth by remodeling the extracellular matrix, promoting angiogenesis (formation of new blood vessels), and secreting signaling molecules that enhance cancer cell survival and invasion.

    Related Terms

    Research 10 of 1000+

    1. Multi-omics analysis unveils the role of cancer-associated fibroblasts in cutaneous squamous cell carcinoma Cancer Cell International · 2025
    2. Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma Frontiers in genetics · 2024
    3. Cellular heterogeneity and microenvironmental control of skin cancer Journal of Internal Medicine · 2020 · 16 citations
    4. 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin Journal of Investigative Dermatology · 2023
    5. Fibrotic enzymes modulate wound‐induced skin tumorigenesis EMBO Reports · 2021 · 15 citations
    6. Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma Proceedings of the National Academy of Sciences of the United States of America · 2024 · 2 citations
    7. Multi-scale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 1 citations
    8. 83 Transcriptomic meta-analysis and deconvolution approaches unveil cellular dynamics in scarring and non-scarring primary lymphocytic alopecias Journal of Investigative Dermatology · 2023
    9. Germline Mutation in ATR in Autosomal- Dominant Oropharyngeal Cancer Syndrome The American Journal of Human Genetics · 2012 · 71 citations
    10. 237 Unveiling Skin Cancers Pathophysiology via the Modeling of Xeroderma Pigmentosum Disease Modeling Using CRISPR-Cas9 Technology Journal of Investigative Dermatology · 2024
    All research results →

    Community 1 of 49

    1. Pattern hair loss before the age of 35 is associated with higher chances of prostate cancer, cardiovascular diseases, and metabolic syndrome later in life Reddit · 7 Jun 2026
    All community results →

    Learn

    — no results

    Try a deeper search in learn →