Multiscale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma

    January 2024 in “ Proceedings of the National Academy of Sciences of the United States of America ”
    Clarisse Gânier, Pavel Mazin, Gabriel Herrera-Oropeza, Xinyi Du-Harpur, Matthew P. Blakeley, Jeyrroy Gabriel, Alexander V. Predeus, Batuhan Çakır, Martin Prete, Nasrat Harun, Jean-François Darrigrand, Alexander Haiser, Saranya P. Wyles, Tanya J. Shaw, Sarah A. Teichmann, Muzlifah Haniffa, Fiona M. Watt, Magnus Lynch
    Image of study
    TLDR The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.
    This document presents a comprehensive spatial atlas of cell populations in healthy human skin and basal cell carcinoma (BCC), achieved through a combination of in vivo optical coherence tomography, single-cell RNA sequencing, spatial global transcriptional profiling, and in situ sequencing. The study found that while cell populations are generally conserved between healthy skin and BCC, mesenchymal cells such as fibroblasts and pericytes show developmental origin signatures. The research suggests that BCC may originate from hair follicles, with cancer-associated fibroblasts being an expansion of a POSTN+ subpopulation linked to hair follicles in healthy skin. Additionally, RGS5+ pericytes are found to be expanded in BCC, indicating a potential role in vascular remodeling. The study proposes that mesenchymal cell identity is influenced by signals from adjacent structures, which may be co-opted in BCC to promote cancer stroma growth. The generated atlas is available for the research community in an interactive online format.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 17 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

    Similar Research

    5 / 1000+ results