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GlossaryRho kinase

enzyme regulating cell shape and movement via the cytoskeleton

Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity Through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17

31 citations , March 2010 in “Molecular Endocrinology”

Androgens like testosterone increase colon muscle contractions by affecting calcium pathways.

research A Novel Immune Competent Murine Hypertrophic Scar Contracture Model: A Tool to Elucidate Disease Mechanism and Develop New Therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

The model helps understand scar contraction and develop new treatments.

research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

24 citations , December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

research Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

64 citations , August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

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community This guy won the jackpot in the hair genetics lottery. He had to pay the taxes (white hair) though

in Chat 2073 upvotes 4 months ago

A man with thick, white hair is admired for his genetics, leading to discussions about hair loss and the preference for white hair over balding. Some speculate about the use of treatments like finasteride.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.