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    Glossary Rho kinase

    enzyme regulating cell shape and movement via the cytoskeleton

    Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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    Research 30 of 747

    1. 557 Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth without affecting the characteristics of the stem cell population Journal of Investigative Dermatology · 2022
    2. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    3. Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in<i>Arabidopsis thaliana</i> bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    4. Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17 Molecular Endocrinology · 2010 · 31 citations
    5. 879 IL-9 mediated human primary keratinocytes invasion is dependent on MLC controlled contractility and independent of MMP activity Journal of Investigative Dermatology · 2018
    6. The TOR–Auxin Connection Upstream of Root Hair Growth Plants · 2021 · 20 citations
    7. Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways Cell Adhesion & Migration · 2012 · 10 citations
    8. A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies Wound Repair and Regeneration · 2014 · 35 citations
    9. Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets Pharmaceutical Research · 2025 · 2 citations
    10. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    11. Efficient establishment of an optimized culture condition for cashmere goat primary hair follicle stem cells 2023
    12. Localizing the ROS Signal Science s STKE · 2005
    13. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    14. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    15. Feronia: A Malectin-Like Domain-Containing Receptor Kinase in Arabidopsis Thalina Scholarworks (University of Massachusetts Amherst) · 2021
    16. The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth 2018 · 109 citations
    17. PAK4 signaling in health and disease: defining the PAK4–CREB axis Experimental & Molecular Medicine · 2019 · 81 citations
    18. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    19. The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome Frontiers in cell and developmental biology · 2023
    20. Tofacitinib for the treatment of severe alopecia areata and variants: A retrospective cohort study of 90 patients Journal of the American Academy of Dermatology · 2017
    21. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    22. A Receptor-Like Kinase Mediates Ammonium Homeostasis and Is Important for the Polar Growth of Root Hairs in<i>Arabidopsis</i> ˜The œPlant cell · 2014 · 107 citations
    23. TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition Cold Spring Harbor Perspectives in Biology · 2017 · 82 citations
    24. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 32 citations
    25. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin Journal of Investigative Dermatology · 2019 · 14 citations
    26. Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet Molecules · 2017 · 13 citations
    27. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    28. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    29. The Arabidopsis Receptor-like Kinase CAP1 Promotes Shoot Growth under Ammonium Stress Biology · 2022 · 5 citations
    30. Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in <i>Arabidopsis thaliana</i> New Phytologist · 2023 · 44 citations