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GlossaryRho kinase

enzyme regulating cell shape and movement via the cytoskeleton

Rho kinase, often abbreviated as ROCK, is an enzyme that plays a crucial role in regulating the shape and movement of cells by affecting the cytoskeleton, which is the cell's structural framework. It is involved in various cellular functions, including contraction, motility, proliferation, and apoptosis, and has been implicated in conditions like hypertension, cancer, and certain types of hair loss, such as alopecia.

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research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research The role of lysophosphatidic acid in the physiology and pathology of the skin

24 citations , March 2019 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

research Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

64 citations , December 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

72 citations , November 2012 in “PloS one”

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

research Non-Edg family LPA receptors: the cutting edge of LPA research

68 citations , July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

research Boosting and Rescuing Epidermal Superior Population from Fresh Keratinocyte Cultures

15 citations , January 2014 in “Stem Cells and Development”

The method increases stem-like cells for better skin regeneration.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway

45 citations , September 2014 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

research Alopecia in a Viable Phospholipase C Delta 1 and Phospholipase C Delta 3 Double Mutant

8 citations , June 2012 in “PloS one”

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium

138 citations , August 2019 in “Stem Cells and Development”

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

research TGF-β family signaling in stem cells

132 citations , February 2013 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

research Smoking and the skin

114 citations , February 2012 in “International Journal of Dermatology”

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis

research Sexual dysfunction in subjects treated with inhibitors of 5α-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis

66 citations , September 2023 in “International Journal of Andrology”

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

research Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

47 citations , June 2019 in “Nature Communications”

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

<i>Acorus calamus</i>: a bio-reserve of medicinal values

research Acorus calamus: a bio-reserve of medicinal values

45 citations , February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology”

*Acorus calamus* has many medicinal benefits but needs more safety research.

Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19

research Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19

36 citations , July 2020 in “Frontiers in Medicine”

Spironolactone might help protect against severe lung problems in COVID-19 patients.

research Repurposing existing drugs for COVID-19: an endocrinology perspective

34 citations , September 2020 in “BMC Endocrine Disorders”

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Drug repositioning using <i>in silico</i> compound profiling

research Drug repositioning using in silico compound profiling

24 citations , December 2009 in “Future Medicinal Chemistry”

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

research Establishment of keratinocyte cell lines from human hair follicles

16 citations , September 2018 in “Scientific reports”

Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.

research Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs

15 citations , November 2015 in “Pharmacopsychiatry”

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

research Latanoprostene bunod ophthalmic solution 0.024% in the treatment of open-angle glaucoma: design, development, and place in therapy

12 citations , December 2018 in “Clinical Ophthalmology”

Latanoprostene bunod effectively lowers eye pressure and is better tolerated than other glaucoma medications.

Interactions between Lower Urinary Tract Symptoms and Cardiovascular Risk Factors Determine Distinct Patterns of Erectile Dysfunction: A Latent Class Analysis

research Interactions between Lower Urinary Tract Symptoms and Cardiovascular Risk Factors Determine Distinct Patterns of Erectile Dysfunction: A Latent Class Analysis

12 citations , December 2013 in “The Journal of Urology”

Men's age, urinary symptoms, and heart health risks create different types of erectile dysfunction.