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Glossary Sonic hedgehog

protein crucial for tissue growth and hair follicle development

Sonic hedgehog (SHH) is a protein that plays a crucial role in regulating the growth and development of various tissues and organs in the body, including hair follicles. It is part of the hedgehog signaling pathway, which is essential for cell differentiation and tissue patterning during embryonic development. Mutations or disruptions in the SHH pathway can lead to developmental disorders and diseases.

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research Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia

39 citations , December 2001 in “JNCI: Journal of the National Cancer Institute”

This study found that enhanced expression of the Sonic hedgehog gene via an adenovirus vector accelerated hair regrowth in mice with chemotherapy-induced alopecia.

research Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems

January 2007 in “Queen Mary Research Online (Queen Mary University of London)”

This study identified interactions between EGF signaling and the GLI proteins in basal cell carcinoma that may contribute to the limited metastasis seen in this skin cancer.

research Gene and tonic: Sonic hedgehog disruption and fetal alcohol syndrome

August 2011 in “Reproductive Toxicology”

research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

research 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification

April 2016 in “Journal of Investigative Dermatology”

This study found that Sonic hedgehog signaling is crucial for Merkel cell development around hair follicles in mice, with Polycomb repressive complex 2 loss causing ectopic Merkel cells across all hair types.

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community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 2 days ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

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