Regulation of Hair Follicle Growth and Development by Different Alternative Spliceosomes of FGF5 in Rabbits

March 2024 in “ Genes ”

Shuang Sun, Bohao Zhao, Jiali Li, Xiyu Zhang, Yao Shan, Zhiyuan Bao, Jiawei Cai, Jie Yang, Chen Yang, Xinsheng Wu

FGF5 FGF5-X1 FGF5-X2 FGF5-X3 hair follicle dermal papilla cells LEF1 CCND1 BCL2 TGFβ gene expression hair growth fibroblast growth factor 5 DPCs transforming growth factor beta

TLDR FGF5 spliceosomes inhibit rabbit hair growth by affecting gene expression.

This study examined the effects of alternative spliceosomes of the FGF5 gene (FGF5-X1, FGF5-X2, FGF5-X3) on hair follicle (HF) growth and development in rabbits. Overexpression of these spliceosomes in dermal papilla cells (DPCs) led to decreased expression of key regulatory genes (LEF1, CCND1, BCL2) and inhibited DPC proliferation, while knockdown had the opposite effect. FGF5-X1 and FGF5-X2 also increased TGFβ mRNA expression. The findings suggest that FGF5 spliceosomes inhibit HF growth by modulating gene expression, providing insights for potential hair growth treatments and improving rabbit wool production.

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