The Role of Wnt10b/β-Catenin Signaling Pathway in Hair Follicle Development in Different Ages of Rex Rabbits

May 2024 in “ Preprints.org ”

Ce Liu, Yin Zhang, Liya Bai, Shuxia Gao, Haitao Sun, Liping Yang, Gongyan Liu

Wnt10b β-catenin hair follicle development TGFβ-BMP IGF1 EGF gene expression protein phosphorylation

Studysummary This study observed that age influences fur quality and hair follicle traits in Rex rabbits, with significant differences in the Wnt10b/β-catenin signaling pathways during hair follicle development, suggesting the ideal slaughter age should not be earlier than 120 days to maximize fur characteristics.

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This study on Rex rabbits examined the Wnt10b/β-catenin signaling pathway's role in hair follicle development across different ages, involving 6 rabbits aged 15 to 150 days. Hair follicle density and development varied with age, peaking at 120 days, with significant changes in gene expression and protein phosphorylation levels. The pathway, along with others like TGFβ-BMP, IGF1, and EGF, was crucial in regulating hair follicle growth and differentiation. The findings suggest that the optimal age for Rex rabbit fur harvesting should be no earlier than 120 days, as this is when hair follicle density and secondary follicle differentiation are highest.

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research The Role of Wnt10b/β-Catenin Signaling Pathway in Hair Follicle Development in Different Ages of Rex Rabbits

1 citations , May 2024 in “Preprints.org”

This study observed that age influences fur quality and hair follicle traits in Rex rabbits, with significant differences in the Wnt10b/β-catenin signaling pathways during hair follicle development, suggesting the ideal slaughter age should not be earlier than 120 days to maximize fur characteristics.

LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis

research LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis

13 citations , April 2020 in “Experimental Cell Research”

This study found that knockdown of PCAT1 inhibited hair follicle regeneration in nude mice by disrupting the miR-329/Wnt10b axis and Wnt/β-catenin signaling, highlighting PCAT1's role in promoting follicle regrowth.

research The Functions of Ocu-miR-205 in Regulating Hair Follicle Development in Rex Rabbits

2 citations , April 2020

This study found that ocu-miR-205 promotes apoptosis in dermal papilla cells, alters hair follicle signaling pathways, and affects hair density in Rex rabbits.

research Hair Follicle Development and Related Gene and Protein Expression in Rex Rabbits During the First 8 Weeks of Life

14 citations , September 2018 in “Asian-Australasian Journal of Animal Sciences”

This study found significant changes in gene and protein expression related to hair follicle development in Rex rabbits' skin during the first 8 weeks of life.

research Properties of Skin Stem Cells and Their Potential Clinical Applications in Modern Dermatology

14 citations , May 2017 in “European journal of dermatology/EJD. European journal of dermatology”

This review summarizes existing research on the potential use of stem cells for treating dermatological disorders, reporting no new clinical findings but highlighting ongoing trials and developments.

research Differential Gene Expression Profiles in Fetal Skin of Rex Rabbits with Different Wool Density

4 citations , September 2016 in “World Rabbit Science”

This study observed that gene expression differences in Rex rabbits with varying wool densities suggest the involvement of specific genes and signaling pathways, including Shh and Eph, in hair follicle development.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.

research Wnt Signaling in Skin Development, Homeostasis, and Disease

260 citations , December 2012 in “Cold Spring Harbor Perspectives in Biology”

This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

77 citations , July 2012 in “Journal of Investigative Dermatology”

The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.