TLDR Hair loss in men might be linked to programmed cell death.
The study "An investigation of apoptosis in androgenetic alopecia" conducted by Michael B Morgan et al. in 2002, examined the role of apoptosis (programmed cell death) in androgenetic alopecia (AGA), a common form of hair loss. The study involved 16 male patients with AGA. The researchers used immunohistochemical markers to assess differences in apoptosis between affected and unaffected areas of the scalp. They found significant differences in the expression of the bcl-2 staining index and TUNEL expression, both markers of apoptosis, between the affected (frontal) and unaffected (occipital) areas of the scalp. This suggested that apoptosis might play a role in AGA, although the exact mechanism was not determined.
47 citations,
April 2000 in “The American journal of pathology” Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
416 citations,
September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
253 citations,
March 1994 in “Developmental dynamics” Apoptosis is essential for human skin development and forming a functional epidermis.
26 citations,
January 1994 in “McGraw-Hill eBooks” Many hair loss conditions can be treated.
138 citations,
August 1985 in “Journal of The American Academy of Dermatology” Minoxidil promotes hair growth in male pattern baldness.
3 citations,
July 2015 in “Biotechnic & histochemistry” Bim and Puma proteins are found in developing mouse hair follicles and are involved in more than just cell death.
2 citations,
January 2003 in “PubMed” Hair loss in men might be linked to programmed cell death.
19 citations,
June 2002 in “American Journal of Dermatopathology” Apoptosis contributes to hair loss in androgenetic alopecia.
