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research The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: Nude mouse as an animal model

18 citations , May 2014 in “International journal of pharmaceutics”

This study found that UVA and UVB exposure increased hydroquinone and sunscreen absorption in nude mouse skin, with less absorption enhancement observed in more lipophilic sunscreens.

research An investigation of apoptosis in androgenetic alopecia.

2 citations , January 2003 in “PubMed”

This study found that in individuals with androgenetic alopecia, the expression of apoptosis-related markers differed significantly between affected and unaffected scalp areas.

research Assessment of markers expressed in human hair follicles according to different skin regions

6 citations , July 2018 in “Advances in Clinical and Experimental Medicine”

This study found that scalp hair follicles had higher expression of cytokeratin 15 and distinct hair layers compared to other body regions, highlighting differences in hair follicle characteristics.

research Differentiation and Apoptosis in Pilomatrixoma

9 citations , January 2011 in “American Journal of Dermatopathology”

This study investigated pilomatrixoma, a benign skin tumor, and found that irregular expression of β-catenin and Lef-1 in transitional cells may contribute to amorphous debris and cyst formation.

research 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification

1 citations , April 2018 in “Journal of Investigative Dermatology”

This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.

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community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 9 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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