Self-Assembling Peptide Inspired by Insulin and Type 1 Insulin-Like Growth Factor for the Treatment of Androgenetic Alopecia

    August 2025 in “ Bioactive Materials
    Xingjie Hu, Lihao Guo, Yinghao Ding … Zhimou Yang
    Studysummary In a murine model of androgenetic alopecia, this study found that the newly designed IGF-1 biomimetic peptide Ac-GFFY-IGF led to faster and superior hair regrowth compared to minoxidil, suggesting potential for improved human therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 20

    1. Innovative Strategies for the Discovery of New Drugs Against Androgenetic Alopecia Expert Opinion on Drug Discovery · 2025
    2. Growth Factors IGF-1 and KGF and Adipose-Derived Stem Cells Promote Migration and Viability of Primary Human Keratinocytes in an In Vitro Wound Model Frontiers in Medicine · 2025
    3. Discovery of a Novel Non-Invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia Journal of Medicinal Chemistry · 2024
    4. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    5. The Psychosocial Impact of Alopecia in Men: A Mixed-Methods Survey Study Skin Health and Disease · 2024
    6. Remodel the Perifollicular Microenvironment via Minoxidil-Loaded Microneedle Patch and Cold Atmospheric Plasma for Treating Androgenetic Alopecia Nano research · 2024
    7. Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment Journal of Medicinal Chemistry · 2023
    8. Androgenetic Alopecia: Therapy Update Drugs · 2023
    9. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    10. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    11. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    12. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    13. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    14. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    15. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    16. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    17. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    18. IGF1R Signaling Acts on the Anagen-to-Catagen Transition in the Hair Cycle Experimental Dermatology · 2017
    19. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    20. Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia Experimental Dermatology · 2014