Self-Assembling Peptide Inspired by Insulin and Type 1 Insulin-Like Growth Factor for the Treatment of Androgenetic Alopecia

    August 2025 in “ Bioactive Materials
    Xingjie Hu, Lihao Guo, Yinghao Ding, Shiyu Nie, Jingqi Fang, Jie Li, Quanhong Han, Dan Ding, Qian Zhang, Tingliang Wang, Ling Wang, Man‐Di Wang, Zhimou Yang
    TLDR Ac-GFFY-IGF peptide is a promising, safe, and effective treatment for hair loss, better than current options.
    The study presents Ac-GFFY-IGF, a novel peptide inspired by insulin and IGF-1, as a promising treatment for androgenetic alopecia (AGA). This peptide shows enhanced stability and skin permeability, outperforming minoxidil in murine models by promoting faster hair regrowth and higher hair quality at lower concentrations. Ac-GFFY-IGF activates the IGF-1 receptor, promoting dermal papilla cell proliferation and resisting DHT-induced apoptosis, without the sexual dysfunction side effects associated with finasteride. The peptide's superior transdermal penetration and stability suggest its potential as an effective non-hormonal topical treatment for AGA, offering improved biosafety and clinical feasibility.
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