Discovery of a Novel Non-Invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia

    December 2024 in “ Journal of Medicinal Chemistry ”
    Xinfei Mao, Weitong Hu, Mingfei Wu … Xiaowu Dong
    Studysummary In this study, researchers discovered a compound called C6 that exhibits excellent skin retention and androgen receptor degradation properties, significantly promoting hair regeneration in a mouse model of androgenetic alopecia following non-invasive topical application, suggesting potential for broader use of PROTACs in treating skin diseases.
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    Research cited in this study 24

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