TLDR Topical PROTACs show promise for treating skin conditions but need better stability and delivery methods.
Proteolysis-targeting chimeras (PROTACs) are being explored for topical use to achieve localized protein degradation with reduced systemic toxicity. This article discusses advances in topical PROTACs, highlighting androgen receptor degraders AH-001 and GT20029, which are in clinical trials for androgenetic alopecia, with GT20029 also being tested for acne. The scope of PROTACs is expanding to target proteins like JAK kinases and BET family members, with potential applications in dermatology, pulmonary and ocular diseases, and cosmetics. Innovative delivery methods, such as liposomes and microneedle systems, are enhancing local delivery. However, challenges remain in optimizing stability, tissue penetration, and target engagement. The article suggests strategic directions to advance the clinical application of topical PROTACs.
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August 2025 in “Plastic and Aesthetic Research” Microneedling can effectively treat hair loss and works well with other treatments, but more research is needed.
June 2024 in “Journal of medicinal chemistry” A new AI-driven method shows promise for treating hair loss with a peptide-based drug.
