TLDR A new AI-driven method shows promise for treating hair loss with a peptide-based drug.
The study presents a top-down design approach for creating a peptide PROTAC (proteolysis-targeting chimera) drug aimed at the androgen receptor to treat androgenetic alopecia. The research, conducted by a collaborative team from various institutions in China, focuses on developing a targeted therapy that degrades the androgen receptor, which is implicated in hair loss. The findings suggest that this novel peptide PROTAC could offer a promising therapeutic strategy for androgenetic alopecia by specifically targeting and degrading the androgen receptor, potentially leading to improved hair growth outcomes.
6 citations,
January 2022 in “Journal of Investigative Dermatology” Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.
2 citations,
November 2023 in “Bioactive materials” New method improves copper peptide delivery for hair growth three times better than current options.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
5 citations,
September 2012 in “Springer eBooks” Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.
1 citations,
December 2023 in “Biomolecules” Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.
38 citations,
June 2015 in “Expert Opinion on Therapeutic Targets” Blocking the prolactin receptor might help treat various diseases, but more research is needed.
