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research A Top-Down Design Approach for Generating a Peptide PROTAC Drug Targeting Androgen Receptor for Androgenetic Alopecia Therapy

June 2024 in “Journal of medicinal chemistry”

This study developed a method for designing peptide-based PROTAC drugs using advanced AI models, successfully identifying peptides that bind to specific receptors and incorporating them into a potential transdermal treatment for androgenetic alopecia.

research Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation

March 2026 in “Bioconjugate Chemistry”

This review highlights the potential of peptide-based PROTACs (pPROTACs) in expanding the target range of protein degraders beyond small-molecule limitations, particularly for undruggable proteins, by utilizing advances in design, conjugation, and bioPROTAC technology.

research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone

98 citations , December 2008 in “Journal of Investigative Dermatology”

This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.

research Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies

68 citations , May 2024 in “International Journal of Molecular Sciences”

This review of acne management strategies highlights current treatments, such as topical and systemic therapies, procedural methods, and dietary changes, while also discussing emerging options like biologics and probiotics as potential future treatments, emphasizing personalized care due to acne's complex nature.

research The human skin as a hormone target and an endocrine gland

146 citations , January 2004 in “Hormones”

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

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Learn

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learn PP405

Did you know PP405 peptides can help protect your follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

learn sh-Polypeptide-7

learn Thymosin Beta 4

learn Vascular Endothelial Growth Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn retinol

Can retinol help enhance the absorption of ingredients like minoxidil or peptides? Retinol may enhance absorption of minoxidil and peptides by modifying skin barrier properties.

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

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Community Join

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community Bryan Johnson's email regarding hair loss and his protocol (including why he doesn't take Fin or Dut).

in Research/Science 6 upvotes 5 months ago

Hair loss treatments include topical and oral minoxidil, low-level laser light therapy, and peptide serums. Bryan Johnson avoids finasteride and dutasteride due to potential side effects, focusing instead on his own protocol with these treatments.

community I Recovered From Severe Hair Loss: My 8-Month Regrowth Recovery — Full Timeline, Photos & Treatment Data

35 upvotes 4 months ago

A 29-year-old male experienced significant hair regrowth over 8 months using a protocol of oral Minoxidil, Dutasteride, Pyrithione Zinc Shampoo, and peptides GHK-CU, BPC-157, and TB-500. The treatment led to improved scalp coverage, reduced hair loss, and thicker hair, although results may vary for others.

community Those using peptide/s w/dermastamping/microneedling- ghk-cu specificially

6 upvotes 5 months ago

The conversation discusses using microneedling with copper peptides, specifically GHK-Cu, for hair loss treatment. Some users combine it with minoxidil and topical finasteride, applying peptides either topically or through injection.

community Natural protocol doesn’t work !

14 upvotes 3 months ago

Natural treatments for hair loss were ineffective for OP, who saw improvement only after starting minoxidil and finasteride. Users suggest that proven medications like finasteride and minoxidil are more effective than natural remedies.

community Randomly came across Copper Peptide for hair regrowth - wondering if this is legit

5 upvotes 10 months ago

Copper peptides, specifically GHK-Cu, are being considered for hair regrowth, though skepticism exists due to questionable product sources. Users suggest finding reputable sources for potential benefits, while acknowledging traditional treatments like Minoxidil and Finasteride.

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