Thermodynamically Stable Ionic Liquid Microemulsions for Topical Delivery and Peptide Application

    November 2023 in “ Bioactive materials
    Tianqi Liu, Ying Li, Xin Zhao, Liguo Zhang, Wei Wang, De Bai, Yanling Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang
    Image of study
    TLDR New method improves copper peptide delivery for hair growth three times better than current options.
    The study introduces a new method for the topical delivery of copper peptides (GHK-Cu), known for promoting hair growth, using a thermodynamically stable ionic liquid-based microemulsion (IL-M). The IL-M system, which combines the high drug solubility of ionic liquids with the high skin permeability of microemulsions, was found to improve the local delivery of copper peptides by approximately three-fold while preserving their biological function. The system was tested on mice and found to increase the expression of growth factors and activate the Wnt/β-catenin signaling pathway, which is involved in hair growth regulation. The IL-M system, named CaT-ME, was found to be stable, biocompatible, and effective in delivering copper peptides, with the permeated amount of copper peptides being 3.18-fold higher than that of the control group. It also significantly increased hair density in mice by stimulating hair follicle cells to secrete VEGF and HGF, promoting growth factor expression and hair growth. The system outperformed commercially available minoxidil in animal experiments.
    Discuss this study in the Community →

    Research cited in this study

    22 / 22 results

    Related Community Posts Join

    6 / 141 results

      community Creating a custom topical growth serum

      in Research/Science  7 upvotes 5 months ago
      A user is creating a custom topical hair regrowth serum using minoxidil, bimatoprost, tretinoin, castor oil, and hyaluronic acid. They are also using dutasteride, oral minoxidil, and castor oil in their current regimen.

      community What happened to that guy who’s been drinking topical minoxidil?!

      in Chat  217 upvotes 1 week ago
      A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

      community GHK-cu/Ahk-cu mix with minoxidil

      in Treatment  2 upvotes 2 months ago
      A user is seeking advice on mixing GHK-cu/AHK-cu with minoxidil for hair loss treatment. They are asking for recommendations on the correct mixing ratios and any experiences with copper peptides.

      community Does it work? Maneup GHK-Cu hair growth serum

      in Treatment  8 upvotes 6 months ago
      The conversation is about the effectiveness of Maneup GHK-Cu hair growth serum, a topical treatment for hair loss. The user is considering trying it but is skeptical due to issues others have had with DIY injections of a similar substance.

      community Ordered copper peptides - how to apply?

      in Treatment  1 upvotes 3 months ago
      Gizzela is unsure about the dosage and frequency of copper peptides and asks if they can be used with Stemoxydine. They seek advice on applying these treatments together.

    Similar Research

    5 / 1000+ results