Isolation and Identification of Hair Growth Potential Fraction from Active Plant Extract of Blumea Eriantha DC Grown in Western Ghat of India: In Silico Study

February 2022 in “ Journal of Ayurveda and integrative medicine ”

Somnath D. Bhinge, Namdeo Jadhav, Dheeraj S. Randive, Mangesh A. Bhutkar, Rohankumar R. Chavan, Bajarang Vasant Kumbhar

dimethyl sulfone Blumea eriantha hair growth Minoxidil in silico in vivo hair follicle skin thickness molecular docking MSM BE extract Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

MSM →

Studysummary This study found that alcoholic extracts of Blumea eriantha DC exhibited significant hair growth activity, primarily attributed to the phytoconstituent Dimethyl sulfone.

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The study isolated dimethyl sulfone from Blumea eriantha DC (BE) extract and found it to promote hair growth, comparable to Minoxidil, through in silico and in vivo methods. Tests on 30 albino mice showed significant hair follicle activity and hair growth with BE extract, particularly at a 3% concentration. Histological analysis confirmed increased skin thickness and hair follicle length, while molecular docking studies supported the efficacy of dimethyl sulfone. The results suggest that BE extract, especially its dimethyl sulfone fraction, is a promising natural remedy for hair growth promotion.

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