Evolving CRBN Ligands Enhance the Drug-Like Properties of Protein Degraders

    July 2026 in “ Journal of Enzyme Inhibition and Medicinal Chemistry ”
    X Ji, L Wang, Xing‐Jie Dai
    Studysummary This review discusses the evolution of Cereblon ligands in PROTAC technology, highlighting chemical innovations that may enhance drug-likeness and applicability in protein degradation, while noting challenges and future research directions.
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