IGF1R Signaling Acts on the Anagen-to-Catagen Transition in the Hair Cycle

January 2017 in “ Experimental Dermatology ”

Mathieu Castela, Fabien Linay, Edwige Roy, Philippe Moguelet, Jie Xu, Martin Holzenberger, Kiarash Khosrotehrani, S. Aractingi

Igf1 receptor Igf1r anagen phase catagen phase hair cycle keratin 15 bulge cells Bmp-4 MED1

Studysummary In this study, deleting the Igf1 receptor in specific skin cells of mice affected hair follicle cycling but not overall skin health, suggesting Igf1r's role in hair cycle regulation through Bmp-4 activation.

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Research cited in this study

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research Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair

30 citations , October 2014 in “Experimental Dermatology”

This study found that leptin from dermal white adipose tissue may regulate hair growth and cycle progression through its receptor on hair follicle epithelium in mice and humans.

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

16 citations , August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations , December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.

research Dietary Isoflavone Increases Insulin-Like Growth Factor-I Production, Thereby Promoting Hair Growth in Mice

29 citations , March 2011 in “The Journal of Nutritional Biochemistry”

Eating isoflavone can help mice grow hair by increasing a growth factor.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations , February 2011 in “Journal of Dermatological Science”

This study found that topical minoxidil modestly extended the anagen phase in mice by activating β-catenin activity in dermal papilla cells.

research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice

55 citations , October 2008 in “American Journal Of Pathology”

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.

IGF1R Signaling Acts on the Anagen-to-Catagen Transition in the Hair Cycle

Research cited in this study

research Leptin of Dermal Adipose Tissue Is Differentially Expressed During the Hair Cycle and Contributes to Adipocyte-Mediated Growth Inhibition of Anagen-Phase Vibrissa Hair

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

research Dietary Isoflavone Increases Insulin-Like Growth Factor-I Production, Thereby Promoting Hair Growth in Mice

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice

research Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

research Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

research Deregulated Expression of c-Myc Depletes Epidermal Stem Cells

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny