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GlossaryPeroxisome Proliferator-Activated Receptors

regulate gene expression related to metabolism and inflammation

Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. They play crucial roles in the metabolism of fats and sugars, inflammation, and cell differentiation, making them significant in conditions like diabetes, obesity, and cardiovascular diseases.

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research Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

105 citations, December 2009 in “Archives of dermatology”

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

research Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics?

60 citations, May 2015 in “Archives of dermatological research”

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

research Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

33 citations, October 2013 in “Journal of The American Academy of Dermatology”

Pioglitazone usually doesn't effectively treat or cure lichen planopilaris.

research Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition

19 citations, September 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.

Preservation of Sebaceous Glands and Peroxisome Proliferator-Activated Receptor Gamma Expression in Central Centrifugal Cicatricial Alopecia

research Preservation of Sebaceous Glands and Peroxisome Proliferator-Activated Receptor Gamma Expression in Central Centrifugal Cicatricial Alopecia

1 citations, July 2018 in “Journal of The American Academy of Dermatology”

Sebaceous glands are often preserved and PPARy expression is constant in some cases of Central Centrifugal Cicatricial Alopecia.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.