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Glossary Peroxisome Proliferator-Activated Receptors

regulate gene expression related to metabolism and inflammation

Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. They play crucial roles in the metabolism of fats and sugars, inflammation, and cell differentiation, making them significant in conditions like diabetes, obesity, and cardiovascular diseases.

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Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

research Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist

105 citations , December 2009 in “Archives of dermatology”

This overview discusses primary cicatricial alopecias, focusing on lichen planopilaris, and highlights the challenges in treatment and the progressive nature of hair loss despite symptom management, without providing new clinical results.

research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?

60 citations , May 2015 in “Archives of dermatological research”

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

research Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis

46 citations , November 2004 in “Lipids”

This study suggests PPAR isotypes play distinct roles in skin, influencing epidermal barrier formation, sebocyte differentiation, and lipid production, with potential implications for treating skin disorders.

research Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

17 citations , February 2018 in “Journal of Investigative Dermatology”

This study found that the PPAR-γ modulator N-acetyl-GED may enhance mitochondrial function in human hair follicles, particularly in outer root sheath keratinocytes.

research Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease

12 citations , November 2012 in “BioMolecular Concepts”

This review discusses the diverse roles of PPARβ/δ in skin health and disease, including its involvement in skin wound healing and inflammatory skin conditions, without presenting new experimental results.

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community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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