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GlossaryPeroxisome Proliferator-Activated Receptors

regulate gene expression related to metabolism and inflammation

Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. They play crucial roles in the metabolism of fats and sugars, inflammation, and cell differentiation, making them significant in conditions like diabetes, obesity, and cardiovascular diseases.

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research Peroxisome Proliferator-Activated Receptors (PPARs) and PPAR Agonists: The Future in Dermatology Therapeutics?

60 citations, May 2015 in “Archives of dermatological research”

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations, October 2000 in “Acta dermato-venereologica”

PPAR alpha may help in hair growth and could be a target for treatment.

research The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair

68 citations, December 2014 in “Cell Biochemistry and Function”

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

research Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

6 citations, May 2020 in “Nutrients”

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “Journal of Endocrinology and Reproduction”

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.